NAD+
Read Reviews ↓ Regular price $49.00 ($1.63/serving)- Formulated with clinically studied ingredients
- Doses informed by published research
- No artificial fillers, colors, or sweeteners
- Manufactured in a cGMP-certified facility
- Independently lab tested for purity and potency
Key Benefits
- Cellular Energy Production — NAD+ is essential for mitochondrial function and ATP synthesis. Levels decline ~50% between ages 40-60.
- DNA Repair Support — NAD+ activates PARP enzymes responsible for repairing damaged DNA strands, supporting genomic stability.
- Sirtuin Activation — Supports the activity of sirtuin proteins (SIRT1-7), key regulators of cellular aging, metabolism, and stress resistance.
- Healthy Aging — Quercetin and resveratrol provide additional senolytic and antioxidant support for healthy cellular aging.
- Metabolic Support — NAD+ is a critical cofactor in over 500 enzymatic reactions, supporting healthy metabolism and energy balance.
- Cognitive Vitality — Supports brain NAD+ levels for mental clarity, focus, and neuroprotection as you age.
How It Works
NAD+ Longevity Formula delivers direct NAD+ combined with synergistic polyphenols:
- Direct NAD+ Delivery: Unlike precursors (NMN, NR) that require enzymatic conversion, our formula provides direct NAD+ at 500mg — the actual molecule your cells need for energy production.
- Sirtuin Pathway: NAD+ fuels sirtuin enzymes (particularly SIRT1 and SIRT3) that regulate mitochondrial biogenesis, autophagy, and cellular stress responses.
- Quercetin Synergy: Quercetin acts as a senolytic — helping clear senescent ("zombie") cells that accumulate with age and drive inflammation.
- Resveratrol Amplification: Resveratrol activates SIRT1 independently of NAD+, creating a dual-activation effect on longevity pathways.
- PARP Support: NAD+ is the essential substrate for PARP enzymes that detect and repair DNA damage, supporting genomic integrity.
Full Ingredient Breakdown
| Ingredient | Amount | Purpose |
|---|---|---|
| NAD+ (Nicotinamide Adenine Dinucleotide) | 500mg | Direct NAD+ for cellular energy, DNA repair, and sirtuin activation. The actual coenzyme — no conversion needed. |
| Quercetin Dihydrate | 250mg | Flavonoid with senolytic properties. Supports clearance of senescent cells and provides antioxidant protection. |
| Trans-Resveratrol | 150mg | Polyphenol that activates SIRT1, supports cardiovascular health, and enhances NAD+ pathway signaling. |
Other Ingredients: Vegetable cellulose capsule, rice flour, magnesium stearate.
Clinical Research
NAD+ Decline & Aging
Research demonstrates that NAD+ levels decline significantly with age, and restoring NAD+ supports mitochondrial function, DNA repair, and healthy aging pathways.
NAD+ & Sirtuin Biology
NAD+ is the essential cofactor for all seven mammalian sirtuins. Supplementation supports sirtuin-mediated benefits including metabolic health and stress resistance.
Quercetin as a Senolytic
Quercetin combined with other senolytics has been shown to selectively clear senescent cells, reducing age-related inflammation and supporting tissue function.
Resveratrol & SIRT1 Activation
Resveratrol activates SIRT1 and supports cardiovascular health, metabolic function, and cellular longevity pathways in human studies.
Every batch is independently verified before it reaches you.
Why AI Selected These Ingredients
The AI analyzed the complete landscape of longevity research to design the optimal NAD+ support formula:
- Direct NAD+ vs. Precursors: While NMN and NR require enzymatic conversion to NAD+, our formula delivers the actual molecule. The AI determined direct delivery reduces dependency on rate-limiting enzymes that decline with age.
- 3-Compound Synergy: The AI identified that NAD+ + Quercetin + Resveratrol target three complementary longevity pathways — energy production, senescent cell clearance, and sirtuin activation.
- 500mg Clinical Dose: The AI set NAD+ at 500mg based on dose-response analysis from clinical literature — significantly above the 100-250mg found in most competitor products.
- Minimal Formulation: The AI intentionally kept this formula focused on three high-impact compounds rather than diluting with 20+ underdosed ingredients. Every milligram is purposeful.
How to Use
Recommended Dose: Take 2 capsules daily.
Best Timing: Morning on an empty stomach or with a light meal for optimal absorption.
Stacking: Highly synergistic with Methyl Blue+ (mitochondrial electron transport), Omega Matrix+ (membrane health), and Core Vitality Matrix+ (cofactor support).
Timeline:
- Week 1-2: Improved energy levels and mental clarity
- Week 4-8: Enhanced metabolic function and recovery
- Month 3+: Cumulative cellular health and longevity benefits
—ï¸ Important Information
- Do not exceed recommended dose.
- Consult your healthcare provider before use if pregnant, nursing, or taking medications.
- Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
NAD+ Cellular Vitality Formula
Direct NAD+ precursor with synergistic polyphenols for cellular energy production, cellular wellness, and cellular vitality support.
Active Ingredient Matrix
| Ingredient | Amount | Wellness Role |
|---|---|---|
| NAD+ (Nicotinamide Adenine Dinucleotide) | 500mg | Direct NAD+ delivery — cellular energy, cellular wellness, sirtuin support |
| Quercetin | Clinical dose | Cellular renewal support polyphenol — cellular cleanup, everyday wellness support |
| Trans-Resveratrol | Clinical dose | Sirtuin activator — cellular vitality support, mitochondrial wellness |
How It Works
- Direct NAD+ Supplementation: 500mg bioavailable NAD+ supports cellular availability
- Sirtuin Support: NAD+ + Resveratrol synergistically support SIRT1-7 longevity enzyme activity
- Cellular Wellness: NAD+ helps fuel enzymes responsible for cellular maintenance
- Cellular Renewal Support: Quercetin supports cellular renewal processes
- Mitochondrial Function: NAD+ contributes to healthy mitochondrial energy production
Suggested Dosing Protocol
Standard Dose: 2 capsules daily
Timing: Morning on empty stomach for optimal absorption
Stacking: Highly synergistic with NMN, B-vitamins, magnesium
Duration: Minimum 60 days for cellular NAD+ support; 90+ days for cellular vitality support
Quality Standards
Frequently Asked Questions About NAD+ Matrix+
What is NAD+ and why does it decline as we age?
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme present in every cell, essential for energy production (ATP via the electron transport chain), cellular wellness (enzyme activity), sirtuin support (longevity proteins), and cellular communication. NAD+ levels decline approximately 50% between ages 40–60, driven by increased cellular demand and reduced biosynthesis. This decline is associated with lower energy levels, impaired cellular maintenance, metabolic wellness changes, and age-related cellular changes — making NAD+ support a major focus in healthy aging science.
What is the difference between direct NAD+ supplementation versus NMN or NR precursors?
NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are NAD+ precursors that must be converted into NAD+ through cellular biosynthesis pathways after absorption. Direct NAD+ supplementation delivers the NAD+ molecule itself. The scientific debate continues: some researchers suggest direct NAD+ is degraded before cellular uptake; more recent data indicates direct supplementation can support tissue NAD+ levels, particularly via certain delivery approaches. Stellar Health NAD+ Matrix+ takes the direct approach at 500mg alongside Quercetin (cellular renewal support, 250mg) and Resveratrol (sirtuin activator, 150mg) for a comprehensive cellular vitality formula. Shilajit Matrix+ in our lineup includes NR as a precursor complement.
What does Quercetin do in NAD+ Matrix+?
Quercetin (250mg standardized from Sophora japonica flower) serves as a cellular renewal support compound — it contributes to healthy cellular maintenance processes that naturally change with age. By supporting a healthy cellular environment, Quercetin helps maintain conditions for NAD+ to be used efficiently. Quercetin also supports healthy NAD+ levels over time by contributing to balanced cellular function. Additionally, Quercetin has broad-spectrum antioxidant activity and supports cardiovascular wellness through multiple pathways.
How long before I notice benefits from NAD+ Matrix+?
Timelines vary by individual. Some users notice increased energy and mental clarity within 1–2 weeks. Cellular NAD+ support typically builds over 3–4 weeks of consistent supplementation. The cellular renewal support of Quercetin and sirtuin support from Resveratrol are cumulative, compounding over months of consistent use. Peer-reviewed research typically uses 90-day minimum supplementation windows to assess meaningful cellular changes. Many users report sustained energy improvements, better recovery from exercise, and sharper mental focus as the primary early benefits — more profound wellness effects emerge with longer-term use.
What is the best way to take NAD+ Matrix+ for maximum benefit?
Take 2 capsules of NAD+ Matrix+ daily in the morning with food. Morning dosing aligns with the body's natural circadian NAD+ rhythms, which are highest during daylight hours. Some individuals find evening NAD+ supplementation may affect sleep due to increased cellular energy. For enhanced benefit, pair with Shilajit Matrix+ (which contains NR for additional NAD+ precursor support and CoQ10 for downstream ATP production) as part of the Ultimate Cellular Energy or Cellular Vitality Protocol stack. Consistent daily use over 90+ days is recommended for the full compounded benefit.
FDA Disclaimer:*These statements have not been evaluated by the FDA. This product is a dietary supplement and is not intended for medical use.*
