The Science
AI-Powered
Formulation
We don’t guess. We don’t follow trends. We analyze thousands of clinical studies to build supplements that are optimized from the ground up.
How It Works
From Research to Formula in Four Steps
Literature Analysis
Our AI scans thousands of peer-reviewed studies from PubMed, examining efficacy data, dosage protocols, and safety profiles for each potential ingredient.
Synergy Mapping
The system identifies ingredient combinations that enhance each other’s bioavailability and efficacy—and flags combinations that interfere.
Dose Optimization
Each ingredient is locked to the clinically-effective dose—the exact amount shown to produce results in human trials. Never less.
Expert Review
AI output is reviewed by human formulators and researchers who validate the final formula before it goes to manufacturing.
Research Standards
Our Research Methodology
Randomized Controlled Trials
We prioritize ingredients with evidence from double-blind, randomized, placebo-controlled trials—the gold standard of clinical research.
Human Studies Only
We don’t rely on animal or in-vitro studies for dosing. Every dose in our formulas is based on human clinical data.
Meta-Analyses Preferred
Where available, we use systematic reviews and meta-analyses that aggregate data across multiple studies for more reliable conclusions.
Continuous Monitoring
Our AI continuously monitors new publications. When significant new evidence emerges, we evaluate whether formula updates are warranted.
Featured Research
Key Studies Behind Our Formulas
A selection of the peer-reviewed research that informs our ingredient choices and dosing protocols.
Magnesium L-Threonate and Cognitive Function
Demonstrated significant improvements in cognitive abilities in older adults with cognitive impairment.
View on PubMed → Nutrients, 2019Ashwagandha and Stress Reduction
Systematic review confirming anxiolytic effects of Ashwagandha root extract across multiple randomized controlled trials.
View on PubMed → Psychopharmacology, 2018Citicoline (CDP-Choline) and Brain Health
Meta-analysis showing citicoline supplementation improves memory and cognitive function in individuals with cognitive deficits.
View on PubMed → Am J Clin Nutr, 2012Vitamin D and Immune Function
Large-scale analysis demonstrating the role of vitamin D supplementation in supporting immune system function.
View on PubMed →Deep Dive
The Clinical Index™ Explained
The Clinical Index is an independent scoring methodology that measures how closely a supplement formula aligns with published clinical evidence. It provides a single, transparent number that consumers can use to evaluate product quality.
How It’s Calculated
- Ingredient Identification — Each ingredient is matched to its corresponding clinical research.
- Dose Comparison — The included dose is compared against the effective dose from clinical trials.
- Form Verification — We verify the ingredient form matches what was studied (e.g., magnesium glycinate vs. oxide).
- Weighted Scoring — Scores are weighted by the strength and quality of supporting evidence.
- Composite Score — Individual scores are aggregated into the final Clinical Index (0–100).
Score Ranges
Ingredient Science
The Power of Synergy
Individual ingredients are important, but how they work together matters just as much. Our AI identifies synergistic combinations that amplify results.
Absorption Enhancers
Ingredients like BioPerine® (black pepper extract) can increase the bioavailability of other compounds by up to 2,000%. We include absorption enhancers where clinically supported.
Cofactor Pairing
Many nutrients require cofactors to function optimally. For example, Vitamin D requires Vitamin K2 for proper calcium metabolism. Our formulas account for these relationships.
Timing Optimization
Some ingredients compete for absorption pathways. We design our formulas to minimize interference and maximize uptake of every ingredient.
See the Science in Action
Explore our products and see exactly how clinical research translates into every formula we make.
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